Plant in Chinese Medicine Seen to Raise SMN Protein Levels in Mouse Model of SMA
A plant used in traditional Chinese medicine boosts the production of functional survival motor neuron (SMN) protein — whose lack underlies…
Articles by Joana Carvalho, PhD
Electrotherapy and Exercise Improves Motor Function in Patient With SMA Type 3, Case Study Reports
Electrotherapy combined with physical exercise may be used to improve motor function in people with spinal muscular atrophy (SMA)…
Problems with Metabolizing Fat Molecules Also Evident, and Worrisome, in SMA Children, Study Says
Although damage to motor neurons characterizes spinal muscular atrophy, problems with lipid (fat) metabolism are an important feature of SMA that…
Severe and Progressive Brain Damage Evident in Young Children with SMA Type 0, Case Report Says
Severe brain abnormalities are evident in children born spinal muscular atrophy type 0, also known as prenatal onset SMA, who…
Clinicians Describe Rare Case of SMA Associated with Epilepsy in Teen
Clinicians have described the case of an Iranian teenager with a rare type of spinal muscular atrophy (SMA) associated…
Small RNA Molecule miR-23a May Have Therapeutic Role in SMA, Study Says
A small RNA molecule called miR-23a can prevent neuron degeneration and muscle wasting by acting as a protective modifier in…
Spinraza Found to Improve, Restore, Motor Function in Children with Late-Onset SMA in Long-term Trial
Long-term treatment with Biogen‘s Spinraza (nusinersen) showed clinically meaningful improvement in the motor function of children ages…
Mouse Study Explores Underlying Cause of Motor Neuron Degeneration in SBMA
A global dysregulation affecting multiple signaling cascades operating inside motor neurons may be the underlying cause of spinal and bulbar…
Zolgensma Defying SMA Type 1 Natural History in STR1VE, Helping Treated Babies to Breathe and Sit, Early Data Show
Zolgensma (AVXS-101), an investigational gene therapy for patients with spinal muscular atrophy (SMA), improves motor function and prolongs…
Valproic Acid Improves Gross Motor Function, but not Respiratory Function in SMA Patients, Review Finds
Valproic acid, or valproate, is a relatively safe drug that improves gross motor function in patients with spinal…