Muscle Thickness Decreases Over Time in SMA Type 1 as Measured by Ultrasound
Children with spinal muscular atrophy (SMA) have weaker muscles than children who are not affected by muscle myopathies and new…
Articles by Maureen Newman
Gene Targeting Therapy Investigated in SMA Cells
When a protein is missing in a cell, as in the case of spinal muscular atrophy (SMA) where survival motor…
Neural Stem Cells From SMA Model Exhibit Altered Growth Kinetics
Researchers have understood the genetic basis of spinal muscular atrophy (SMA) for many years. Mutations in the gene that encodes…
Researchers Targeting Astrocytes Discover Treatment Benefits in SMA-Induced Mice
Previously thought to be a disease only of motor neurons, spinal muscular atrophy (SMA) is now also known to be…
SMA Patient Muscle is Deficient in Mitochondrial Biogenesis
Patients with spinal muscular atrophy (SMA) exhibit many signs of mitochondrial paucity. Weakened muscles and other pathologic muscle changes…
SMA Severity Correlates with DNA Methylation
Patients with spinal muscular atrophy (SMA) are subdivided into four categories based on disease severity and age of diagnosis,…
Key Neuromuscular Junction Found To Be Impaired in SMA
Researchers in the Division of Pharmacology, Department of Biochemistry and Molecular Biology at Kobe University Graduate School of Medicine…
New PCR Method Helps Determine SMA Type
Determining the exact mutations responsible for spinal muscular atrophy (SMA) can be difficult. The condition is caused by complete…
Correcting Splicing Error Restores SMN in SMA Patient Cells
Perhaps the result of a gene duplication event 5 million years ago, humans have two copies of the gene…
Modeling Disease And Restoring SMN Expression: Leading-Edge Research in SMA
“This is an exciting time for spinal muscular atrophy (SMA) patients, families and researchers,” indicated an article published in…