Lindsey Shapiro, PhD,  science writer—

Lindsey earned her PhD in neuroscience from Emory University in Atlanta, where she studied novel therapeutic strategies for treatment-resistant forms of epilepsy. She was awarded a fellowship from the American Epilepsy Society in 2019 for this research. Lindsey also previously worked as a postdoctoral researcher, studying the role of inflammation in epilepsy and Alzheimer’s disease.

Articles by Lindsey Shapiro

Muscle composition improves for children on Spinraza: Study

Muscle-related body composition measures improved in children with spinal muscular atrophy (SMA) types 2 and 3 who were treated with Spinraza (nusinersen), and the improvements correlated with better motor function, a study found. “Indicators of muscle mass increased in children with SMA types 2 and 3 as treatment…

Amino acid balance could play role in SMA, study finds

The balance of amino acids capable of influencing neurological function is disrupted in patients with spinal muscular atrophy (SMA) and in mouse models, a study found. Observed changes in patients were partially normalized after treatment with the disease-modifying therapy Spinraza (nusinersen). Treatment with one of the amino acids,…

Zolgensma into spinal canal drives SMA type 2 motor gains

Treatment with OAV101 IT, a formulation of the gene therapy Zolgensma (onasemnogene abeparvovec-xioi) that’s delivered directly into the spinal canal, safely led to motor improvements for children with spinal muscular atrophy (SMA) type 2 who were at least 2 years old,  top-line results from the Phase 3 STEER…

Swallowing problems in SMA may be declining since advent of DMTs

Swallowing function may have improved in spinal muscular atrophy (SMA) patients since disease-modifying therapies (DMT) have become available, a review study suggests. The analysis showed problems with swallowing were prevalent in the years before the emergence of DMTs and that studies after the treatments became available indicated stabilizations…

Altered body fat, metabolic disturbances common in SMA adults

Adults with spinal muscular atrophy (SMA) showed alterations in body composition and metabolic disturbances, including changes in blood sugar and fats, that could leave them vulnerable to cardiometabolic complications, a study shows. People with SMA type 2 and those who weren’t ambulatory, meaning they couldn’t walk, showed the…