As Demand Soars, Pricey Spinraza Has Experts Wondering How to Decide Who Benefits Most from Treatment

As Demand Soars, Pricey Spinraza Has Experts Wondering How to Decide Who Benefits Most from Treatment

Several experts are wondering how best to determine which spinal muscular atrophy (SMA) patients will benefit most from treatment with Spinraza (nusinersen), due both to its high cost and growing demand.

Dr. Claudia A. Chiriboga, a neurology and pediatrics professor at Columbia University Medical Center, said Spinraza must be given every four months at high doses, a regimen that increases demand and creates a managing problem for clinicians.

“There are many children and adults waiting for treatment,” Chiriboga said in an article by Thomas R. Collins that appeared in Neurology Today. “So, how to fairly and equitably prioritize treatment across the patient population is a challenge and also how to assess risk-benefit, for maybe children who are too weak and (for whom) the procedure might be a problem if they need intubation.”

In December, the U.S. Food and Drug Administration (FDA) approved Biogen‘s Spinraza, making it not only the first FDA-approved therapy for SMA, but also one of the most expensive drugs ever approved by the agency.

The drug’s per-dose price tag is $125,000. It helps infants with SMA survive longer and achieve motor milestones.

“Given the extreme [high] cost of the medication and our finite resources, how do we best determine who will benefit from the medication as function that can be recovered, and how do we assess response to medication that justifies continued use?” Chiriboga asked.

“We’re still grappling with these issues,” she said. “We’ve identified the central functions such as walking or sitting and critical functions such as operating their wheelchair that we’d need to preserve. But we don’t have all the answers, and some insurance plans are taking it upon themselves to make those determinations for us, with some criteria that don’t make all that much sense.”

Dr. Charlotte J. Sumner, an associate professor of neurology at Johns Hopkins University, said final results for the Phase 3 ENDEAR clinical trial (NCT02193074) emphasize the need for early treatment of this disease.

“The early and efficient diagnosis of SMA is really critical to attaining the maximal therapeutic benefit from nusinersen or other drugs that are coming in the pipeline. Particularly for infantile SMA, time is motor function,” Sumner said, adding that if neonatal screening for SMA becomes the norm, “we’re going to have to develop infrastructures to be able to efficiently enroll patients in treatment.”

While these results are promising and show that infants can tolerate the spinal injections, the procedure is still challenging. Therefore, “these infants are still very ill and require excellent standard of care,” she said.

It’s still not clear if Spinraza remains effective over time, Sumner said, even though babies who have received the drug for the past four years show that Spinraza hasn’t lost its effectiveness.

“A big question, of course, given the burden of administering this drug, is whether at some point the drug can be withdrawn later in life,” she said. “We do think of SMA somewhat as a disease of development. And perhaps after the developmental period has completed, we can actually withdraw the drug.”


    • Daisy Nguyen says:

      Hi Rachel
      Could you tell me hơ to contact German’s hospital where patient type 1 can buy Spinraza at 4,700 usd? I know one child in Vietnam who is also SMA patient type 1 and their parents are nearly hopeless because they cannot find the medicine to save their child. Please help

        • Hang says:

          Excuses me, Sinh. Could you tell me who Vanessa Christie-Brown is or this is a foundation? I have my sister diagnosed SMA type 3 two years ago, I’m trying to find a treatment for her, her muscles gradually become weaker and weaker.Could you please help me? I would very much appreciate your help.

  1. Gemma seaber says:

    My daughter is 8 years old and has Sma type 2. We are desperate for her to receive spinraza treatment and I was under the impression from neurology team that it is currently only available to babies with type 1. I have since read up that a male adult with type 3 in America has started treatment. How is this so when there are children in much more desperate need of this drug than he is im sure! As much as I hope in future it becomes available to EVERYONE with Sma as it should be. I cannot understand why adults in other countries who are stronger are receiving this treatment before those in the U.K.? Can you advise me further to clear up this matter. I would very much appreciate a reply from you. I’m hopeful my daughter will be taking part in a spinraza trial in London at great Ormamd street hospital in sept this year. Kindest regards Gemma seaber

    • Kristin says:

      I’m 23 and trying to get dosed but I’m in Texas. America is dispensing the drug pretty well. There is a facebook group called SPINRAZA Information for Spinal Muscular Atrophy (SMA) that can help answer some questions you may have.

  2. Mohsen says:

    I’m from Iran. unfortunately there isn’t spinraza in my country. My friend become weaker and weaker every day.
    how can i buy spinraza? please help me.

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