I’ve never noticed any particular change from a specific dose, but I have noticed general changes over time. I’m getting my 10th dose next week, and while I’ve gotten back a little strength, my grip strength is definitely better, though even with that I’m not where I was maybe 5 years ago, the most noticeable change is my recovery time. Before Spinraza I was at the point where if I had a busy day or exerted myself, I’d have to try to rest for several days to get back to where I was, which was getting me in the bad cycle that I needed to be active to maintain strength, but if I was active I’d be too tired to do anything for days which would make me lose strength. Now I feel like if I’m tired, I’m back to where I was in a day rather than 3, or if my arm gives out doing something I just have to wait a few minutes for it to come back rather than it feeling dead all day.
I’d say I’m definitely better than I was before Spinraza, but it hasn’t been some sort of miracle treatment where I’m able to do stuff I never thought I’d do again or anything like that. I feel like I’m sort of maintaining about where I was maybe a year before I started it, and that’s enough for me to keep living independently which is all I hoped for.